The Jamaican, who retained her 100m-200m title double in Tokyo, clocked a new world lead of 10.54s.
Only American Florence Griffith-Joyner has run faster, when she set her world record of 10.49s in 1988.
Thompson-Herah’s Jamaican compatriots Shelly-Ann Fraser-Pryce and Shericka Jackson were second and third respectively in a repeat of the Tokyo podium.
American Sha’Carri Richardson, who missed the Olympics because of a one-month suspension after testing positive for marijuana, finished last.
Earlier this season, Fraser-Pryce ran 10.63s to become the second fastest Woman in history behind Griffith-Joyner, only to see her time usurped by 29-year-old Thompson-Herah with 10.61s as she retained her Olympic title in Tokyo.
(BBC)