The explosive-laden drones targeted a graduation ceremony attended by cadets’ families, and women and children were among the dead.
The army blamed “terrorist groups backed by known international forces”.
There was no immediate claim from the rebels and jihadists battling the government in the country’s civil war.
The drone attack is believed to have been launched from opposition-held areas north-west of Homs.
Later, first responders from the White Helmets reported that five civilians had been killed in intense government artillery and missile strikes on several cities, towns and villages in the opposition stronghold of Idlib province.
Syria’s state news agency, Sana, quoted a statement from the General Command of the Armed Forces as saying that several drones carrying explosives targeted the Homs military academy just after the afternoon graduation ceremony had ended.
The statement said the armed forces “considers this act an unprecedented criminal one, and affirms that it will respond with full force and determination to these terrorist groups wherever they are”.
In a later report the agency quoted Health Minister Hassan al-Gabbash saying the strike had injured more than 200 people and that six women and six children were among the dead.
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