The Russian, 24, closed out the opener but ever-dogged, Murray fought back in the second set and broke in the ninth game on his way to levelling the match.
He had breakpoint in Safiullin’s opening service game but could not convert before the Russian benefitted from a fortunate net deflection to break in the next game.
Murray lost his rhythm after that as Safiullin raced away with the deciding set and even though the former British number one saved a series of match points on his own serve, it was ultimately in vain.
Three-time Grand Slam winner Murray has a wildcard for the Metz Open next week. (BBC)