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Mix-And-Match vaccines have big benefit – Study

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The trial is the first major US study to compare the effects of using different vaccines as boosters from the initial shot or shots. The complicated, 9-arm trial involved over 450 people and measured the effects from giving a booster shot of the Moderna Inc, Pfizer Inc.-BioNTech SE or Johnson & Johnson vaccines to those who had originally gotten a different vaccine.

Overall, the results found that mixing-and-matching resulted in comparable or higher levels of neutralizing antibodies compared to same-vaccine boosting, the researchers said in the preprint posted on medRxiv.org. Rates of adverse events were similar across all the different booster groups, the study found.

“These data suggest that if a vaccine is approved or authorized as a booster, an immune response will be generated regardless of the primary Covid-19 vaccination regimen,” the researchers said in their conclusion.

The results from the ongoing trial have not yet been peer reviewed and published in a medical journal. More detail about the study is expected to be disclosed Friday afternoon at a meeting of FDA advisory panel, where researchers conducting the trial are scheduled to give a presentation on their early findings.

Ads by Mixing and matching boosters has become an increasingly important issue. Many countries outside the US have used the method for in an attempt to maximize vaccine effectiveness or avoid rare side effects that have been associated with some shots. – FRANCE 24

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